+49-421-2208-228 info@prep4u.de

Do you have a substance that needs to be purified ?

Specialists with over 20 years of experience

Top Equipment

Worldwide references

From mg up to kg

A special case is the separation of image and mirror image – the enantioseparation. Although the physical and chemical properties of enantiomers match to a large extent, they often have completely different biological activities. Therefore, it is often necessary to test the biological activities of both enantiomers and to use only the active enantiomerically pure compound. For this reason, the need for production processes for enantiomerically pure products has increased enormously in recent years.

However, the separation of enantiomers is a rather tricky task because most of the physical properties leading to a separation are identical. Preparative chromatography with chiral adsorbents is one way to solve this problem. Prep4U has the most common chiral stationary phases and selects the one that separates your enantiomers.

It is important to find conditions that combine maximum productivity with highest purity.

Chiral HPLC

The separation of image and mirror image – enantioseparation – is a special case.
Although the physical and chemical properties of enantiomers match to a large extent, they often have completely different biological activities.

Preparative HPLC

We have profound and longstanding experience in the area of preparative HPLC –
regardless whether it is 100mg or 100kg that needs to be separated.
We have a careful look at your compound and decide individually which separation method is the most effective.

Simulated Moving Bed (SMB)

SMB can be used for the separation of larger quantities (from 5-10kg).

This involves continuous chromatography whereby up to 90% less solvent can be used as this is recirculated.

Supercritical fluid chromatography (SFC)

State of the art is the so called Supercritical Fluid Chromatography (SFC), which uses CO2 as eluent.
This protects your sensitive substances and is extremely environmentally friendly (Green Chemistry).
We can perform small scale and lage scale separations.

Common detectors are available, such as UV, DAD, MS, RI, CAD and NMR.

Location

Fahrenheitstraße 1
28359 Bremen